A new Spider-Man game has been announced for the usual round of platforms, Spider-Man: Web of Shadows. The game takes place in the mainstream Marvel universe, and allows players to guide Spider-Man's path as heroic or anti-hero in a free-roaming New York. There's supposed to be a good amount of cusomization in your combos and aerial combat also comes into play.
A title to watch to be sure. Check out the announcement trailer below or on the main site. All those tentacles look very symbiote-like to me.